There are three different difficulties in Neoquest: Normal, Evil, and Insane. Normal is the easiest. The monsters here are average in hit points and the items are easy to find. Evil is the next stage after completing Normal. In Evil, the monsters are harder and the items, besides artifacts, are harder to find. In Insane, the monsters are way harder and the items are much more rarer.

In Neoquest, there are three different movement types: Normal, Hunting, and Sneaking. In Normal, monsters will attack you on a regular basis. In Hunting, monsters will attack you more often because you are hunting them (I highly recommend this movement type only if you want more experience). In Sneaking, monsters will attack you less often because you are sneaking away from this (only do this if the monsters are too strong for you).