Eleus Batrin is an important NPC. He is in the center house of Neopia City. He gives you directions in the game and can upgrade your weapons after killing Xantan the Foul. After you killed Scaleback, he will tell you to go to sunny town where Gali Yoj is (see bottom). After telling you to go to Sunny City, he will not give you any more directions. The rest of the journey is up to you.
Boraxis the Healer
Boraxis the Healer lives in the northwest corner of Neopia City. He is an important NPC if you are injured and if you are near Neopia City. He is the only healer in the game.
Choras Tillie lives in the southeast corner of Neopia City. He makes level 2 armor. The only way to obtain the armor is by traveling in the dank cave because the items he asks for are in the dank cave.
Morax Dorangis lives in the southwest corner of Neopia City. All he does is give you the first stage of armor. Other than that, he does nothing. The items he asks for can be found a few spaces west of Neopia City.
Lummock is just an average NPC. He lives in the northeast corner of Neopia City. He gives you the first stage of weapons that you don't have but you need the appropriate items. Other than giving you weapons, he does nothing.
Rikti is in the second floor of the dank cave. He is a useless NPC since he doesn't do anything.
Denethrir the Scholar
Denethrir is somewhat an important NPC. He makes the next stage of weapons and these weapons have special effects. If you were wielding a Volcano Wand, there will be a random chance that the wand can cast a spell that can do additional fire damage.
Margoreth the Teacher
Margoreth is a teacher who got stuck in the ruins. She has nothing important and she doesn't do anything.
Tylix is in the garden of the ruins. He doesn't do anything and doesn't give you anything.
Pomanna is also a prisoner in the ruins. She can be found near the lake to Scaleback. She has no important information and does nothing.
Korabric is on the fifth tower floor of the ruins. The only time you can visit him is by defeating Kreai, Gors, and Scaleback. He has no important information except to tell you to go to Eleus about the Rusty Medallian.
Mokti is Rikti's older brother. He lives in Swamp Edge City. He and Leirobas make armor for you. The items that they need can be found in the desert of roo.
Like I said earlier, Leirobas can make armor for you. But he is also a useful NPC. He is an important NPC if you want to upgrade your weapons. He is the one to talk to if you want the Jewels of Power.
Erick is found in the Temple of Roo. He is needed to upgrade your weapons after killing the Archmagus of Roo. It is easy to remember how to make the weapons since he asks for only 3 items: the Coruscating Gem, a Carved Oak Staff, and a Jewel of Power.
Mr. Irgo can be found near the entrance of the first Techo Cave. He makes armor for you. These armor each have a special effect. Each armor requires three items that can be found in the Techo Mountain Caves.
Gali Yoj is one of the game's most important NPC. She lives in Sunny Town. She will repair the Rusty Medallion you got from Scaleback and it will turn into the Keladrian Medallion. She will also give you information on the other places you haven't explored.
Faleinn's ghost can be seen after you defeated Faleinn and removed Kal Panning from its curse. Faleinn's ghost will tell you about your final battle against Jahbal and the history of the Circle of Twelve.
The Gate Keeper
The Gate Keeper can be found in the cave to the Two Rings. He guards the door so no one can enter Two Rings without a key. He has no other information to give you.