A lot of people have been asking other people which is the best skill to choose in Neoquest. The answer is: which skill that sounds right for you. The skills are grouped into five categories: Fire, Ice, Shock, Spectral, and Life. The best way (for me) is to spread out your skill points and use a weapon that you like. To help you out choosing, below is what each element can do:

Fire: additional damage

Ice: additional damage and stunning opponents

Shock: stuns opponents

Spectral: evades attacks

Life: heals you